Proteintech

GART Monoclonal Antibody (2A11E2), CoraLite® Plus 488

GART Antibody in Immunocytochemistry (ICC/IF)

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GART Antibody (CL488-67939) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using CoraLite® Plus 488 GART antibody (CL488-67939, Clone: 2A11E2 ) at dilution of 1:200.

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产品信息

CL488-67939

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2A11E2

抗原

Recombinant protein

查看免疫原

偶联物

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

激发/发射光谱

493/522 nm

形式

Liquid

纯化类型

Protein G

保存液

PBS with 50% glycerol, 0.5% BSA

内含物

0.05% ProClin 300

保存条件

-20° C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI SISDHTALAQ FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA AQLESSKRFA KEFMDRHGIP TAQWKAFTKP EEACSFILSA DFPALVVKAS GLAAGKGVIV AKSKEEACKA VQEIMQEKAF GAAGETIVIE ELLDGEEVSC LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP QVSNDLLLKI KDTVLQRTVD GMQQEGTPYT GILYAGIMLT KNGPKVLEFN CRFGDPECQV ILPLLKSDLY EVIQSTLD

靶标信息

MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。