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GATA2 Antibody (710242) in ICC/IF
Immunofluorescent analysis of GATA2 in U2OS cells using a GATA2 Recombinant Rabbit Polyclonal Antibody (Product # 710242) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green) (Image A). Nuclei were stained using DAPI (Image B) and actin stained with Alexa Fluor 594 phalloidin (red) (image C). Image D is a composite image showing nuclear localization of GATA2.
产品信息
710242
产品规格
种属反应
Human,
Rabbit
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
11HCLC
抗原
Peptide corresponding to amino acids 396-409 of human GATA binding protein 2
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532644
产品详细信息
This antibody is predicted to react with equine, non-human primate, mouse, rabbit and rat based on sequence homology.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; MGC2306; uterine GATA-4 transcription factor
基因别名: DCML; GATA2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769
Entrez Gene ID: (Rabbit) 100008832, (Human) 2624
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
C2H2 zinc finger domain binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
transcription, DNA-templated
transcription from RNA polymerase II promoter
phagocytosis
positive regulation of cytosolic calcium ion concentration
heart development
blood coagulation
organ morphogenesis
tissue development
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
response to lipid
somatic stem cell population maintenance
regulation of histone acetylation
eosinophil fate commitment
inner ear morphogenesis
mast cell degranulation
negative regulation of fat cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
digestive tract development
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
negative regulation of fat cell proliferation
GABAergic neuron differentiation
negative regulation of neural precursor cell proliferation
regulation of forebrain neuron differentiation
