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GATA2 Monoclonal Antibody (2G11)

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GATA2 Antibody in Western Blot (WB)

GATA2 Antibody in Western Blot (WB)

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GATA2 Antibody (H00002624-M04) in WB

GATA2 monoclonal antibody (M04), clone 2G11. Western Blot analysis of GATA2 expression in HeLa S3 NE.

GATA2 Antibody in Western Blot (WB)

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GATA2 Antibody in Western Blot (WB) — GATA2 monoclonal antibody (M04), clone 2G11. Western Blot analysis of GATA2 expression in HeLa S3 NE.

产品信息

H00002624-M04

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫细胞化学 (ICC/IF)

10-100 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG

分类

Monoclonal

类型

Antibody

克隆号

2G11

抗原

GATA2 (AAH18988, 1 a.a. approximately 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GK

靶标信息

GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Endothelial transcription factor GATA-2; FLJ45948; GATA-binding protein 2; MGC2306

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基因别名: DCML; GATA2; IMD21; MONOMAC; NFE1B

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UniProt ID: (Human) P23769

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Entrez Gene ID: (Human) 2624

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RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding zinc ion binding C2H2 zinc finger domain binding DNA-binding transcription factor

参与通路

negative regulation of transcription from RNA polymerase II promoter urogenital system development cell fate determination neuron migration embryonic placenta development transcription, DNA-templated transcription from RNA polymerase II promoter phagocytosis positive regulation of cytosolic calcium ion concentration heart development blood coagulation organ morphogenesis tissue development regulation of primitive erythrocyte differentiation ventral spinal cord interneuron differentiation cell differentiation in hindbrain commitment of neuronal cell to specific neuron type in forebrain central nervous system neuron development pituitary gland development response to lipid somatic stem cell population maintenance regulation of histone acetylation eosinophil fate commitment inner ear morphogenesis mast cell degranulation negative regulation of fat cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of megakaryocyte differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter cell maturation digestive tract development homeostasis of number of cells within a tissue positive regulation of phagocytosis positive regulation of phagocytosis, engulfment definitive hemopoiesis semicircular canal development negative regulation of fat cell proliferation GABAergic neuron differentiation negative regulation of neural precursor cell proliferation regulation of forebrain neuron differentiation