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产品信息
CF810246
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI2E2
抗原
Full length human recombinant protein of human GCH1 produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dystonia 14; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I
基因别名: DYT14; DYT5; DYT5a; GCH; GCH1; GTP-CH; GTP-CH-1; GTPCH; GTPCH1; HPABH4B
UniProt ID: (Human) P30793, (Mouse) Q05915, (Rat) P22288
Entrez Gene ID: (Human) 2643, (Mouse) 14528, (Rat) 29244
tetrahydrobiopterin biosynthetic process
nitric oxide biosynthetic process
regulation of blood pressure
regulation of lung blood pressure
response to lipopolysaccharide
response to interferon-gamma
response to tumor necrosis factor
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
vasodilation
dopamine biosynthetic process
pteridine-containing compound biosynthetic process
negative regulation of blood pressure
tetrahydrofolate biosynthetic process
response to pain
neuromuscular process controlling posture
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
protein homooligomerization
protein heterooligomerization
regulation of removal of superoxide radicals
protein complex assembly
metabolic process
dihydrobiopterin metabolic process
