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产品信息
PA5-121070
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCN2 (NP_001013725.2).
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914642
产品详细信息
Positive test controls include: HeLa, 293T, Mouse liver, Mouse brain, Rat liver, Rat brain.
Immunogen sequence: MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACGPVK EPPEINLVLY PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSRL EELAKKHCGE VMIFELAYHV QSFLSEHNKP PPKSFHEEML ERRAQEEQQR LLEAKRKEEQ EQREILHEIQ RRKEEIKEEK KRKEMAKQER LEIASLSNQD HTSKKDPGGH RTAAILHGGS PDFVGNGKHR ANSSGRSRRE RQYSVCNSED SPGSCEILYF NMGSPDQLMV HKGKCIGSDE QLGKLVYNAL
靶标信息
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; mGCN2
基因别名: 2610011M03; EIF2AK4; GCN2; KIAA1338; MGCN2; PVOD2
UniProt ID: (Human) Q9P2K8, (Mouse) Q9QZ05
Entrez Gene ID: (Human) 440275, (Mouse) 27103, (Rat) 114859
tRNA binding
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
eukaryotic initiation factor eIF2 binding
aminoacyl-tRNA synthetase
non-receptor serine/threonine protein kinase
translational protein
positive regulation of defense response to virus by host
adaptive immune response
T cell activation involved in immune response
positive regulation of adaptive immune response
regulation of translational initiation
protein phosphorylation
cell cycle arrest
learning
long-term memory
regulation of translational initiation by eIF2 alpha phosphorylation
viral translation
negative regulation of translational initiation in response to stress
negative regulation of CREB transcription factor activity
cellular response to amino acid starvation
cellular response to UV
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
induction by virus of host autophagy
negative regulation by host of viral genome replication
negative regulation of neuron differentiation
negative regulation of translational initiation
protein autophosphorylation
defense response to virus
regulation of feeding behavior
regulation of eIF2 alpha phosphorylation by amino acid starvation
cellular response to cold
positive regulation of translational initiation in response to starvation
positive regulation of long-term synaptic potentiation
neuron projection extension
cellular response to leucine starvation
cellular response to starvation
positive regulation of gene expression
phosphorylation
negative regulation of translation
endoplasmic reticulum unfolded protein response
response to endoplasmic reticulum stress
regulation of translational initiation in response to stress
