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Invitrogen
GDF15 Polyclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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GDF15 Antibody (PA5-29782) in WB
Western blot was performed using Anti-GDF15 Polyclonal Antibody (Product # PA5-29782) and a ~34kDa band corresponding to GDF15 was observed across the cell lines tested except Jurkat which is reported to be negative. The expression of protein also increased in HCT 116 upon thapsigargin treatment. Whole cell extracts (30ug lysate) of LNCaP (Lane 1), LNCaP treated with PTI (1X for 4 hr) (Lane2), HCT 116 (Lane 3), HCT 116 treated with PTI (1X for 4hr) (Lane 4), HCT 116 treated with thapsigargin (16uM for 16hr) and PTI (1X for 4 hr) (Lane 5), ... View More
产品信息
PA5-29782
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 308 of Human GDF-15
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547256
产品详细信息
Recommended positive controls: 293T, A431, HeLa.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; NAG1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta
基因别名: GDF-15; GDF15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
UniProt ID: (Human) Q99988
Entrez Gene ID: (Human) 9518
signal transduction
transforming growth factor beta receptor signaling pathway
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
positive regulation of myoblast fusion
