Bioss

GDF8 Polyclonal Antibody, Alexa Fluor™ 488

查看其他17个Myostatin抗体

产品信息

BS-23012R-A488

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-5,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

免疫组化（冰冻） (IHC (F))

1:50-1:200

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human GDF8 (301-375).

查看免疫原

偶联物

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

激发/发射光谱

499/520 nm 查看光谱

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: compact; GDF-8; growth differentiation factor 8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin

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基因别名: Cmpt; GDF8; MSLHP; MSTN

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UniProt ID: (Human) O14793, (Rat) O35312, (Mouse) O08689

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Entrez Gene ID: (Human) 2660, (Rat) 29152, (Mouse) 17700

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receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding identical protein binding molecular_function growth factor

参与通路

positive regulation of defense response to virus by host transforming growth factor beta receptor signaling pathway muscle organ development response to heat response to gravity positive regulation of pathway-restricted SMAD protein phosphorylation skeletal muscle atrophy negative regulation of muscle hypertrophy response to muscle activity ovulation cycle process response to testosterone negative regulation of kinase activity regulation of apoptotic process skeletal muscle tissue regeneration regulation of MAPK cascade response to estrogen response to ethanol negative regulation of myoblast differentiation positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway muscle cell cellular homeostasis cell development negative regulation of skeletal muscle tissue growth response to electrical stimulus negative regulation of protein kinase B signaling SMAD protein signal transduction cellular response to dexamethasone stimulus mitophagy in response to mitochondrial depolarization xenophagy negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation negative regulation of myoblast proliferation response to glucocorticoid growth