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产品信息
15251-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GEMIN8 Fusion Protein Ag6774 (1-242 aa encoded by BC003607)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody recognize GEMIN8 (28-32 kDa) only.
Immunogen sequence: MAAVKASTS KATRPWYSHP VYARYWQHYH QAMAWMQSHH NAYRKAVESC FNLPWYLPSA LLPQSSYDNE AAYPQSFYDH HVAWQDYPCS SSHFRRSGQH PRYSSRIQAS TKEDQALSKE EEMETESDAE VECDLSNMEI TEELRQYFAE TERHREERRR QQQLDAERLD SYVNADHDLY CNTRRSVEAP TERPGERRQA EMKRLYGDSA AKIQAMEAAV QLSFDKHCDR KQPKYWPVIP LKF (1-242 aa encoded by BC003607)
靶标信息
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: family with sequence similarity 51, member A1; gem (nuclear organelle) associated protein 8; Gem-associated protein 8; Gemin-8; Protein FAM51A1
基因别名: FAM51A1; GEMIN8
UniProt ID: (Human) Q9NWZ8
Entrez Gene ID: (Human) 54960
