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The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: gastric inhibitory peptide receptor; Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
基因别名: GIP-R; Gippr; GIPR; Gm1081; Gm160; PGQTL2; RATGIPPR
UniProt ID: (Human) P48546, (Mouse) Q0P543, (Rat) P43219
Entrez Gene ID: (Human) 2696, (Dog) 484439, (Mouse) 381853, (Rat) 25024
分子生物学功能:
transmembrane signal receptor