Product References
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Phytotherapy research : PTR
He CH,Lv JM,Khan GJ,Duan H,Wang W,Zhai KF,Zou GA,Aisa HA
Sat Jul 01 00:00:00 EDT 2023
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Phytotherapy research : PTR
He CH,Lv JM,Khan GJ,Duan H,Wang W,Zhai KF,Zou GA,Aisa HA
Sat Jul 01 00:00:00 EDT 2023
Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway.
Ecotoxicology and environmental safety
Cao WS,Zhao MJ,Chen Y,Zhu JY,Xie CF,Li XT,Geng SS,Zhong CY,Fu JY,Wu JS
Wed Mar 01 00:00:00 EST 2023
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.
Cell death and differentiation
Zhou X,He Y,Pan X,Quan H,He B,Li Y,Bai G,Li N,Zhang Z,Zhang H,Li J,Yuan X
Wed Feb 01 00:00:00 EST 2023
Gut microbiota dysbiosis promotes the development of epithelial ovarian cancer via regulating Hedgehog signaling pathway.
Gut microbes
Hu X,Xu X,Zeng X,Jin R,Wang S,Jiang H,Tang Y,Chen G,Wei J,Chen T,Chen Q
Thu Jun 08 00:00:00 EDT 2023
Gut microbiota dysbiosis promotes the development of epithelial ovarian cancer via regulating Hedgehog signaling pathway.
Gut microbes
Hu X,Xu X,Zeng X,Jin R,Wang S,Jiang H,Tang Y,Chen G,Wei J,Chen T,Chen Q
Thu Jun 08 00:00:00 EDT 2023
Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia.
Journal of ethnopharmacology
Han L,Li T,Wang Y,Lai W,Zhou H,Niu Z,Su J,Lv G,Zhang G,Gao J,Huang J,Lou Z
Mon Jun 12 00:00:00 EDT 2023
Profilin1 Promotes Renal Tubular Epithelial Cell Apoptosis in Diabetic Nephropathy Through the Hedgehog Signaling Pathway.
Diabetes, metabolic syndrome and obesity : targets and therapy
Mai L,He G,Chen J,Zhu J,Chen S,Yang H,Zhang M,Hou X,Ke M,Li X
Mon Jun 19 00:00:00 EDT 2023
Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208.
Cell death & disease
Han J,Chen X,Wang J,Liu B
Fri Feb 03 00:00:00 EST 2023
Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Qiu FS,Wang JF,Guo MY,Li XJ,Shi CY,Wu F,Zhang HH,Ying HZ,Yu CH
Fri Sep 01 00:00:00 EDT 2023
Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis.
Neural plasticity
Meng P,Zhang X,Li D,Yang H,Lin X,Zhao H,Li P,Wang Y,Wang X,Ge J
Wed Jan 18 00:00:00 EST 2023
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia.
Acta pharmacologica Sinica
Li XW,Ran JH,Zhou H,He JZ,Qiu ZW,Wang SY,Wu MN,Zhu S,An YP,Ma A,Li M,Quan YZ,Li NN,Ren CQ,Yang BX
Wed Feb 01 00:00:00 EST 2023
Effect of kaempferol on hedgehog signaling pathway in rats with --chronic atrophic gastritis - Based on network pharmacological screening and experimental verification.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Tu W,Hong Y,Huang M,Chen M,Gan H
Sat Jan 01 00:00:00 EST 2022
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Cancer immunology research
Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M
Tue Feb 01 00:00:00 EST 2022
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Cancer immunology research
Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M
Tue Feb 01 00:00:00 EST 2022
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Cancer immunology research
Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M
Tue Feb 01 00:00:00 EST 2022
Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.
American journal of physiology. Heart and circulatory physiology
Angelini A,Ortiz-Urbina J,Trial J,Reddy AK,Malovannaya A,Jain A,Entman ML,Taffet GE,Cieslik KA
Mon Aug 01 00:00:00 EDT 2022
Metformin regulates macrophage polarization via the Shh signaling pathway to improve pulmonary vascular development in bronchopulmonary dysplasia.
IUBMB life
Xiang X,Zhou L,Lin Z,Qu X,Chen Y,Xia H
Tue Mar 01 00:00:00 EST 2022
BRD4 promotes the migration and invasion of bladder cancer cells through the Sonic hedgehog signaling pathway and enhances cisplatin resistance.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Liu T,Zhang Z,Wang C,Huang H,Li Y
Fri Apr 01 00:00:00 EDT 2022
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Journal of molecular and cellular cardiology
Wang Q,Chai L,Zhang Q,Wang J,Liu J,Chen H,Wang Y,Chen Y,Shen N,Xie X,Li M
Sat Oct 01 00:00:00 EDT 2022
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Journal of molecular and cellular cardiology
Wang Q,Chai L,Zhang Q,Wang J,Liu J,Chen H,Wang Y,Chen Y,Shen N,Xie X,Li M
Sat Oct 01 00:00:00 EDT 2022
Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.
JCI insight
Shi H,Wang H,Zhang C,Lu Y,Yao J,Chen Z,Xing G,Wei Q,Cao X
Tue Feb 22 00:00:00 EST 2022
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
International journal of molecular sciences
Yang G,Lu S,Jiang J,Weng J,Zeng X
Fri May 27 00:00:00 EDT 2022
GPC2 deficiency inhibits cell growth and metastasis in colon adenocarcinoma.
Open medicine (Warsaw, Poland)
Lin L,He Y,Ni Z,Zhang M,Liu J,Mao Q,Huang B,Lin J
Fri Mar 04 00:00:00 EST 2022
Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade.
Phytotherapy research : PTR
Chen L,Liu M,Yang H,Ren S,Sun Q,Zhao H,Ming T,Tang S,Tao Q,Zeng S,Meng X,Xu H
Thu Sep 01 00:00:00 EDT 2022
The Effects of Hedgehog Signaling Pathway on the Proliferation and Apoptosis of Melanoma Cells.
Journal of oncology
Peng ZP,Huang SF,Li JJ,Tang XK,Wang XY,Li HM
Sat Apr 30 00:00:00 EDT 2022
Maternal sevoflurane exposure affects neural stem cell differentiation in offspring rats through NRF2 signaling.
Neurotoxicology
Zhang Y,Kuai S,Zhang Y,Xue H,Wu Z,Zhao P
Thu Dec 01 00:00:00 EST 2022
Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.
Antioxidants (Basel, Switzerland)
Li G,Deng Y,Li K,Liu Y,Wang L,Wu Z,Chen C,Zhang K,Yu B
Wed Nov 16 00:00:00 EST 2022
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Journal of cellular and molecular medicine
Ma L,Li C,Lian S,Xu B,Lv H,Liu Y,Lu J,Ji H,Li S,Guo J,Yang H
Sun Aug 01 00:00:00 EDT 2021
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Journal of cellular and molecular medicine
Ma L,Li C,Lian S,Xu B,Lv H,Liu Y,Lu J,Ji H,Li S,Guo J,Yang H
Sun Aug 01 00:00:00 EDT 2021
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Canadian journal of physiology and pharmacology
Ding F,Yang S
Wed Sep 01 00:00:00 EDT 2021
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Brain sciences
Fu J,Li L,Huo D,Zhi S,Yang R,Yang B,Xu B,Zhang T,Dai M,Tan C,Chen H,Wang X
Fri Jan 08 00:00:00 EST 2021
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Brain sciences
Fu J,Li L,Huo D,Zhi S,Yang R,Yang B,Xu B,Zhang T,Dai M,Tan C,Chen H,Wang X
Fri Jan 08 00:00:00 EST 2021
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Brain sciences
Fu J,Li L,Huo D,Zhi S,Yang R,Yang B,Xu B,Zhang T,Dai M,Tan C,Chen H,Wang X
Fri Jan 08 00:00:00 EST 2021
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Brain sciences
Fu J,Li L,Huo D,Zhi S,Yang R,Yang B,Xu B,Zhang T,Dai M,Tan C,Chen H,Wang X
Fri Jan 08 00:00:00 EST 2021
Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma.
Journal of Cancer
Chen D,Kang X,Li Z,Chen L,Ma Q,Fan P
Fri Oct 22 00:00:00 EDT 2021
Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma.
Journal of Cancer
Chen D,Kang X,Li Z,Chen L,Ma Q,Fan P
Fri Oct 22 00:00:00 EDT 2021
Decreased Indian hedgehog signaling activates autophagy in endometriosis and adenomyosis.
Reproduction (Cambridge, England)
Zhou Y,Peng Y,Xia Q,Yan D,Zhang H,Zhang L,Chen Y,Zhao X,Li J
Mon Feb 01 00:00:00 EST 2021
Decreased Indian hedgehog signaling activates autophagy in endometriosis and adenomyosis.
Reproduction (Cambridge, England)
Zhou Y,Peng Y,Xia Q,Yan D,Zhang H,Zhang L,Chen Y,Zhao X,Li J
Mon Feb 01 00:00:00 EST 2021
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Cell death & disease
Wang H,Wei W,Zhang ZY,Liu Y,Shi B,Zhong W,Zhang HS,Fang X,Sun CL,Wang JB,Liu LX
Fri Dec 17 00:00:00 EST 2021
Microtubule Stabilization Enhances the Chondrogenesis of Synovial Mesenchymal Stem Cells.
Frontiers in cell and developmental biology
Li J,Sun Z,Lv Z,Jiang H,Liu A,Wang M,Tan G,Guo H,Sun H,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Shi D
Wed Nov 10 00:00:00 EST 2021
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Scientific reports
Peng C,Li X,Ye Z,Wu W
Tue Aug 10 00:00:00 EDT 2021
Wogonin inhibits the growth of HT144 melanoma via regulating hedgehog signaling-mediated inflammation and glycolysis.
International immunopharmacology
Li L,Ji Y,Zhang L,Cai H,Ji Z,Gu L,Yang S
Wed Dec 01 00:00:00 EST 2021
Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signaling Pathway to Ameliorate Cognitive Dysfunction by Kaixin San in Multi-Infarct Dementia Rats.
Oxidative medicine and cellular longevity
Li X,Wen W,Li P,Fu Y,Chen H,Wang F,Dai Y,Xu S
Thu Dec 30 00:00:00 EST 2021
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Frontiers in cell and developmental biology
Cao W,Li Y,Sun H,Yang C,Zhu J,Xie C,Li X,Wu J,Geng S,Wang L,Sun L,Geng G,Han H,Zhong C
Fri Aug 06 00:00:00 EDT 2021
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Frontiers in cell and developmental biology
Cao W,Li Y,Sun H,Yang C,Zhu J,Xie C,Li X,Wu J,Geng S,Wang L,Sun L,Geng G,Han H,Zhong C
Fri Aug 06 00:00:00 EDT 2021
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Frontiers in cell and developmental biology
Cao W,Li Y,Sun H,Yang C,Zhu J,Xie C,Li X,Wu J,Geng S,Wang L,Sun L,Geng G,Han H,Zhong C
Fri Aug 06 00:00:00 EDT 2021
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Frontiers in cell and developmental biology
Cao W,Li Y,Sun H,Yang C,Zhu J,Xie C,Li X,Wu J,Geng S,Wang L,Sun L,Geng G,Han H,Zhong C
Fri Aug 06 00:00:00 EDT 2021
Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.
Cancer science
Guo K,Wang P,Zhang L,Zhou Y,Dai X,Yan Y,Chen Y,Wasan HS,Yu J,Ruan S,Sun L
Fri Oct 01 00:00:00 EDT 2021
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Cell death discovery
Zhu T,Zheng J,Zhuo W,Pan P,Li M,Zhang W,Zhou H,Gao Y,Li X,Liu Z
Sat May 29 00:00:00 EDT 2021
Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.
Nutrition and cancer
Sun H,Zhang T,Liu R,Cao W,Zhang Z,Liu Z,Qian W,Wang D,Yu D,Zhong C
Wed Sep 08 00:00:00 EDT 2021
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
Biochemical and biophysical research communications
Lu Y,Zhang M,Wei Q,Chen Z,Xing G,Yao J,Cao X
Fri Oct 15 00:00:00 EDT 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
Molecular cancer
Gu Y,Wang Y,He L,Zhang J,Zhu X,Liu N,Wang J,Lu T,He L,Tian Y,Fan Z
Thu Oct 14 00:00:00 EDT 2021
Meningitic Escherichia coli α-hemolysin aggravates blood-brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling.
Molecular brain
Fu J,Li L,Huo D,Yang R,Yang B,Xu B,Yang X,Dai M,Tan C,Chen H,Wang X
Mon Jul 19 00:00:00 EDT 2021
Benzidine promotes the stemness of bladder cancer stem cells via activation of the Sonic hedgehog pathway.
Oncology letters
Wang D,Xie D,Bi L,Wang Y,Zou C,Chen L,Geng H,Qian W,Li Y,Sun H,Wang X,Lu Y,Yu D,Zhong C
Mon Feb 01 00:00:00 EST 2021
Long noncoding RNA LINC00460 promotes the progression of cervical cancer via regulation of the miR-361-3p/Gli1 axis.
Human cell
Li F,Zhu W,Wang Z
Fri Jan 01 00:00:00 EST 2021
Identification of a potent antagonist of smoothened in hedgehog signaling.
Cell & bioscience
Fan J,Li H,Kuang L,Zhao Z,He W,Liu C,Wang Y,Cheng SY,Chen W
Tue Mar 02 00:00:00 EST 2021
Repair of spinal cord injury in rats via exosomes from bone mesenchymal stem cells requires sonic hedgehog.
Regenerative therapy
Jia Y,Yang J,Lu T,Pu X,Chen Q,Ji L,Luo C
Wed Dec 01 00:00:00 EST 2021
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Journal of neurochemistry
Wu J,He J,Tian X,Luo Y,Zhong J,Zhang H,Li H,Cen B,Jiang T,Sun X
Mon Jun 01 00:00:00 EDT 2020
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Journal of neurochemistry
Wu J,He J,Tian X,Luo Y,Zhong J,Zhang H,Li H,Cen B,Jiang T,Sun X
Mon Jun 01 00:00:00 EDT 2020
Cigarette smoke supports stemness and epithelial-mesenchymal transition in bladder cancer stem cells through SHH signaling.
International journal of clinical and experimental pathology
Sun X,Song J,Li E,Geng H,Li Y,Yu D,Zhong C
Wed Jul 15 00:00:00 EDT 2020
Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways.
European review for medical and pharmacological sciences
Hou HW,Xue P,Wang Y,Li YK
Tue Dec 01 00:00:00 EST 2020
A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis.
Molecular cancer therapeutics
Wang Q,Jia S,Wang D,Chen X,Kalvakolanu DV,Zheng H,Wei X,Wen N,Liang H,Guo B,Zhang L
Tue Dec 01 00:00:00 EST 2020
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
International journal of food sciences and nutrition
Ge M,Zhang L,Cao L,Xie C,Li X,Li Y,Meng Y,Chen Y,Wang X,Chen J,Zhang Q,Shao J,Zhong C
Thu Aug 01 00:00:00 EDT 2019
Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.
Phytotherapy research : PTR
Zhang Q,Cao WS,Wang XQ,Zhang M,Lu XM,Chen JQ,Chen Y,Ge MM,Zhong CY,Han HY
Tue Oct 01 00:00:00 EDT 2019
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Nature communications
Zhu R,Gires O,Zhu L,Liu J,Li J,Yang H,Ju G,Huang J,Ge W,Chen Y,Lu Z,Wang H
Fri Jun 28 00:00:00 EDT 2019
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Nature communications
Zhu R,Gires O,Zhu L,Liu J,Li J,Yang H,Ju G,Huang J,Ge W,Chen Y,Lu Z,Wang H
Fri Jun 28 00:00:00 EDT 2019
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.
Oncology letters
Li E,Zhang T,Sun X,Li Y,Geng H,Yu D,Zhong C
Sun Sep 01 00:00:00 EDT 2019
