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产品信息
12678-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GLIS3 Fusion Protein Ag3366 (429-775 aa encoded by BC033899)
偶联物
Unconjugated
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: LKIHLRSHT GEKPYLCQHP GCQKAFSNSS DRAKHQRTHL DTKPYACQIP GCTKRYTDPS SLRKHVKAHS SKEQQARKKL RSSTELHPDL LTDCLTVQSL QPATSPRDAA AEGTVGRSPG PGPDLYSAPI FSSNYSSRSG TAAGAVPPPH PVSHPSPGHN VQGSPHNPSS QLPPLTAVDA GAERFAPSAP SPHHISPRRV PAPSSILQRT QPPYTQQPSG SHLKSYQPET NSSFQPNGIH VHGFYGQLQK FCPPHYPDSQ RIVPPVSSCS VVPSFEDCLV PTSMGQASFD VFHRAFSTHS GITVYDLPSS SSSLFGESLR SGAEDATFLQ ISTVDRCPSQ LSSVYTEG (429-775 aa encoded by BC033899)
靶标信息
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GLI-similar 3; GLIS family zinc finger 3; OK/KNS-cl.4; Zinc finger protein 515; Zinc finger protein GLIS3
基因别名: 4833409N03Rik; E330013K21Rik; GLIS3; NDH; RGD1565505; ZNF515
UniProt ID: (Human) Q8NEA6, (Mouse) Q6XP49
Entrez Gene ID: (Human) 169792, (Rat) 680671, (Mouse) 226075
DNA binding
metal ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
