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产品信息
PA1-84890
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal region of rat glycine receptor alpha 1 subunit.
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
Ammonium bicarbonate
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2110058
产品详细信息
PA1-84890 detects a band at ~48 kDa in rat spinal cord lysates.
Reconstitute with 0.1 mL PBS. For long term storage, the addition of 0.09% sodium azide is recommended. Prior to reconstitution, store at 4ºC. After reconstitution, store undiluted at -20ºC, avoiding freeze/thaw cycles.
Rabbit anti glycine receptor recognizes an epitope within the N-terminal region (NT) of glycine receptor alpha 1 and alpha 2 subunits.
靶标信息
Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glycine receptor 48 kDa subunit; glycine receptor alpha 2 subunit; Glycine receptor alpha 2 subunit (glycine receptor, neonatal); Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; Glycine receptor subunit alpha-2; glycine receptor, alpha 1 subunit; glycine receptor, alpha 2; glycine receptor, alpha 2 subunit; glycine receptor, alpha-2 polypeptide
基因别名: GLR; GLRA1; GLRA2; Glyr; GLYRA1; HKPX1; nmf11; oscillator; ot; RNNEOGLY; spasmodic; spd; STHE
UniProt ID: (Human) P23415, (Human) P23416, (Mouse) Q64018, (Rat) P07727, (Rat) P22771, (Mouse) Q7TNC8
Entrez Gene ID: (Human) 2741, (Human) 2742, (Mouse) 14654, (Rat) 25674, (Rat) 24397, (Mouse) 237213
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
glycine-gated chloride ion channel activity
metal ion binding
extracellular ligand-gated ion channel activity
chloride channel activity
extracellular-glycine-gated ion channel activity
ligand-gated ion channel
action potential
startle response
regulation of respiratory gaseous exchange by neurological system process
ion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
acrosome reaction
visual perception
adult walking behavior
ion transmembrane transport
regulation of membrane potential
neuromuscular process controlling posture
protein homooligomerization
protein heterooligomerization
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
righting reflex
inhibitory postsynaptic potential
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
chloride transmembrane transport
positive regulation of acrosome reaction
synapse assembly
spinal cord development
transport
anion transport
chemical synaptic transmission
regulation of respiratory gaseous exchange
neuromuscular process
