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GM2A Antibody (PA5-109773) in WB
Western blot analysis of GM2A in extracts of various cell lines. Samples were incubated with GM2A Polyclonal antibody (Product # PA5-109773) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5 min.
产品信息
PA5-109773
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 24-193 of human GM2A (NP_000396.2).
偶联物
形式
Liquid
浓度
1.64 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855184
产品详细信息
Immunogen sequence: HLKKPSQLSS FSWDNCDEGK DPAVIRSLTL EPDPIIVPGN VTLSVMGSTS VPLSSPLKVD LVLEKEVAGL WIKIPCTDYI GSCTFEHFCD VLDMLIPTGE PCPEPLRTYG LPCHCPFKEG TYSLPKSEFV VPDLELPSWL TTGNYRIESV LSSSGKRLGC IKIAASLKGI
靶标信息
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cerebroside sulfate activator protein; Ganglioside GM2 activator; GM2 ganglioside activator protein; GM2-AP; SAP-3; shingolipid activator protein 3; Sphingolipid activator protein 3
基因别名: AA408702; AW215435; GM2-AP; Gm2a; SAP-3
UniProt ID: (Mouse) Q60648
Entrez Gene ID: (Mouse) 14667, (Rat) 282838
lipid metabolic process
sphingolipid metabolic process
ganglioside catabolic process
learning or memory
oligosaccharide catabolic process
lipid storage
positive regulation of catalytic activity
neurological system process
neuromuscular process controlling balance
ganglioside metabolic process
lipid transport
positive regulation of hydrolase activity
membrane fusion
