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Immunogen sequence: SESLVVCDVA EDLVEKLRKF RFRKETNNAA IIMKIDKDKR LVVLDEELEG ISPDELKDEL PERQPRFIVY SYKYQHDDGR VSYPLCFIFS SPVGCKPEQQ MMYAGSKN
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.
This protein, which is phosphorylated following phorbol ester stimulation, is important for the nervous system. It causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. Overexpression of GMF in astrocytes has been shown to enhance brain-derived neurotrohic factor (BDNF) production. GMF expression is increased by exercise, and the protein is crucial for exercise-induction of BDNF. Through BDNF production, GMF appears to play a role in neuroprotection. In thymoma, T-cell development is maintained by GMF; being produced by the tumor cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DNA for thyroid hormone receptor binding site (276bp); Glia maturation factor beta; glia maturation factor, beta; GMF-beta
基因别名: 3110001H22Rik; 3110001O16Rik; AI851627; C79176; D14Ertd630e; GMF; GMFB
UniProt ID: (Human) P60983, (Rat) Q63228, (Mouse) Q9CQI3
Entrez Gene ID: (Human) 2764, (Rat) 81661, (Mouse) 63985