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Immunogen sequence: HGQDFDQRAR EEFRPTIYSN VIKGMRVLVD AREKLHIPWG DNSNQQHGDK MMSFDTRAPM AAQGMVETRV FLQYLPAIRA LWADSGIQNA YDRRREFQLG ES
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G alpha 13; G alpha-13; G-protein subunit alpha-13; Galpha 13; guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding protein subunit alpha-13
基因别名: G13; GNA13
UniProt ID: (Human) Q14344
Entrez Gene ID: (Human) 10672
分子生物学功能:
heterotrimeric G-protein