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Immunogen sequence: EMEQLRQEAE QLKKQIADAR KACADVTLAE LVSGLEVVGR VQMRTRRTLR GHLAKIYAMH WATDSKLLVS ASQDGKLIVW DSYTTNKVHA IPLRSSWVMT CAYAPSGNFV ACGGLDNMCS IYNLKSREGN VKVSRELSAH TGYLSCCRFL DDNNIVTSSG DTTCALWDIE TGQQKTVFVG HTGDCMSLAV SPDFNLFISG ACDASAKLWD VREGTCRQTF TGHESDINAI CFFPNGEAIC TGSDDASCRL FDLRADQELI CFSHESIICS ITSVAFSLSG RLLFAGYDDF NCNVWDSMKS ERVGILSGHD NRVSCLGVTA DGMAVATGSW DSFLKIWN
Heterotrimeric guanine nucleotide-binding proteins in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein beta-subunit; G protein, beta-3 subunit; gbb3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein, beta 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein, beta-3 subunit; hypertension associated protein; Transducin beta chain 3
基因别名: CSNB1H; Gnb-3; GNB3
UniProt ID: (Human) P16520, (Mouse) Q61011, (Rat) P52287
Entrez Gene ID: (Pig) 100154522, (Human) 2784, (Mouse) 14695, (Rat) 60449
分子生物学功能:
heterotrimeric G-protein