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Immunogen sequence: SIDLQEPLQ KKFCFPPVKE NISQDIDHIL ETLSALAVDL GGTNLRVAIV SMKGEIVKKY TQFNPKTYEE RINLILQMCV EAAAEAVKLN CRILGVGIST GGRVNPREGI VLHSTKLIQE WNSVDLRTPL SDTLHLPVWV DNDGNCAALA ERKFGQGKGL ENFVTLITGT GIGGGIIHQH ELIHGSSFCA AELGHLVVSL DGPDCSCGSH GCIEAYASGM ALQREAKKLH DEDLLLVEGM SVPKDEAVGA LHLIQAAKLG NAKAQSILRT AGTALGLGVV NILHTMNPSL VILSGVLASH YIHIVKDVIR QQALSSVQDV DVVVSDLVDP ALLGAASMVL DYTTRRIY (376-722 aa encoded by BC121179)
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
基因别名: DMRV; GLCNE; GNE; IBM2; NM; Uae1
UniProt ID: (Human) Q9Y223
Entrez Gene ID: (Human) 10020
分子生物学功能: DNA-binding transcription factor