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产品信息
PA5-20524
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide near the carboxy terminus of the human GPAT1.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155813
产品详细信息
A suggested positive control is rat brain tissue lysate.
PA5-20524 can be used with blocking peptide PEP-0644.
靶标信息
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: glycerol 3-phosphate acyltransferase, mitochondrial; Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1; P90; RP11-426E5.2
基因别名: GPAM; GPAT; GPAT1; KIAA1560
UniProt ID: (Human) Q86TA3, (Mouse) Q61586, (Rat) P97564
Entrez Gene ID: (Human) 57678, (Mouse) 14732, (Rat) 29653
fatty acid metabolic process
acyl-CoA metabolic process
phosphatidic acid biosynthetic process
response to glucose
response to fructose
positive regulation of triglyceride biosynthetic process
response to activity
CDP-diacylglycerol biosynthetic process
triglyceride biosynthetic process
response to nutrient levels
cellular response to insulin stimulus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
response to cadmium ion
regulation of cytokine secretion
defense response to virus
fatty acid homeostasis
phospholipid homeostasis
negative regulation of activation-induced cell death of T cells
interleukin-2 secretion
lipid metabolic process
triglyceride metabolic process
glycerophospholipid metabolic process
metabolic process
phospholipid biosynthetic process
cellular lipid metabolic process
