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GPCR G2A is a G-protein linked receptor for lysophosphatidylcholine (LPC). It may play a role as a sensor of LPC levels at sites of inflammation to limit tissue-infiltrating-cells and progression to overt autoimmune disease and functions at the G2/M checkpoint to delay mitosis. It also may serve as a mechanism for T and B cells, and other cell types, to slow their proliferation and repair damaged DNA. It is highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus, but weakly expressed in heart and lung. In atherosclerotic plaques, expression was observed around the lipid core and at the shoulder region. It is induced by DNA-damaging agents.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein-coupled receptor G2A; G2 accumulation protein; MGC99642; Probable G-protein coupled receptor 132
基因别名: G2A; GPR132
UniProt ID: (Human) Q9UNW8, (Mouse) Q9Z282
Entrez Gene ID: (Human) 29933, (Mouse) 56696