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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Elephant (94%); Monkey, Marmoset (88%); Bat (81%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein-coupled receptor PGR10; G-protein coupled receptor PGR10; Probable G-protein coupled receptor 149
基因别名: GPR149; IEDA; PGR10
UniProt ID: (Human) Q86SP6
Entrez Gene ID: (Human) 344758
分子生物学功能: G-protein coupled receptor transmembrane signal receptor