Search Thermo Fisher Scientific
图: 1 / 2
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
GPR65 also known as TDAG8 is a transmembrane protein belonging to the G protein coupled receptor super family with 337-amino acid and 90% similarity and 81% identity in the 7 transmembrane domains of its mouse homolog. It has 3 potential N-linked glycosylation sites and is expressed predominantly in lymphoid organs and cancer tissues with increased expression during activation-induced death of T-cell hybridomas. Two major transcripts of 4.5 kb and 1.8 kb are found in peripheral blood leukocytes and functions as a novel proton-sensing receptor. It couples to adenylyl cyclase and psychosine and is also actively involved in the establishment of immunological autotolerance. GPR65 has a role in cellular transformation by RhoA activation and actin rearrangement under conditions accompanying tissue acidosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G-protein coupled receptor 25; G-protein coupled receptor 65; Psychosine receptor; T cell death associated protein 8; T-cell death-associated gene 8 protein
基因别名: Dig1; Gpcr25; GPR65; hTDAG8; TDAG8
UniProt ID: (Human) O75819, (Mouse) Q61038
Entrez Gene ID: (Human) 8477, (Rat) 299242, (Mouse) 14744