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GPX4 Antibody (PA5-19710) in WB
Western blot was performed using Anti-GPX4 Polyclonal Antibody (Product # PA5-19710) and a ~19.5 kDa band was observed across the panel tested. Tissue lysates (30 µg lysate) of Mouse Testis (Lane 1), Rat Testis (Lane 2), Mouse Liver (Lane 3), whole cell extracts (30 µg lysate) of MCF-7 (Lane 4), HeLa (Lane 5) and Daudi (Lane 6) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product ... View More
产品信息
PA5-19710
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH derived from within residues 150 to the C-terminus of Human Glutathione Peroxidase 4.
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10988012
产品详细信息
This antibody is predicted to react with many species based on sequence homology.
靶标信息
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glutathione peroxidase 4; GPx-4; HGNC:4556; PHGPx; phospholipid hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; sperm nuclei glutathione peroxidase; sperm nucleus glutathione peroxidase
基因别名: GPx-4; GPX4; GSHPx-4; MCSP; mtPHGPx; PHGPx; SMDS; snGPx; snPHGPx
UniProt ID: (Human) P36969, (Mouse) O70325, (Rat) P36970
Entrez Gene ID: (Human) 2879, (Mouse) 625249, (Rat) 29328
phospholipid metabolic process
response to oxidative stress
multicellular organism development
lipoxygenase pathway
oxidation-reduction process
cellular oxidant detoxification
chromatin organization
glutathione metabolic process
spermatogenesis
hydrogen peroxide catabolic process
regulation of inflammatory response
aging
response to estradiol
