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产品信息
PA5-79324
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Gremlin 1 (151-184aa TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2746440
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; Gremlin-1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2
基因别名: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREM1; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
UniProt ID: (Human) O60565, (Rat) O35793
Entrez Gene ID: (Human) 26585, (Rat) 50566
cell morphogenesis
angiogenesis
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of leukocyte chemotaxis
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
apoptotic process
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
proximal/distal pattern formation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
endothelial cell migration
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
positive regulation of NF-kappaB transcription factor activity
regulation of focal adhesion assembly
positive regulation of telomerase activity
limb development
negative regulation of pathway-restricted SMAD protein phosphorylation
ureteric bud formation
positive regulation of protein tyrosine kinase activity
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of receptor activity
positive regulation of cardiac muscle cell differentiation
