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GRIK3 (GluK3) (extracellular) Antibody (AGC-040-200UL) in IHC (F)
Expression of GluR7 in mouse hippocampus and rat cerebellum - Immunohistochemical staining of immersion-fixed, free floating frozen brain sections using Anti-GRIK3 (GluK3) (extracellular) Antibody (#AGC-040), (1:400).A. GluR7 staining (red) in mouse hippocampus reveals expression in the pyramidal (P) layer (arrow).B. GluR7 staining (red) in rat cerebellum reveals expression in the Purkinje (P) layer (horizo... View More
产品信息
AGC-040-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DGPNAQVMNAEEH, corresponding to amino acid residues 46-58 of rat kainate receptor GluK3, Extracellular, N-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA5; Excitatory amino acid receptor 5; GluK3; GluR-7; glutamate receptor; Glutamate receptor 7; Glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic, kainate 3
基因别名: 9630027E11; EAA5; GLR7; GluK3; Glur-7; GLUR7; GluR7-3; GluR7a; GRIK3
UniProt ID: (Human) Q13003, (Rat) P42264, (Mouse) B1AS29
Entrez Gene ID: (Human) 2899, (Rat) 298521, (Mouse) 14807
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
G-protein coupled receptor binding
ionotropic glutamate receptor activity
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
receptor activity
ion channel activity
protein binding
transmembrane signal receptor
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
regulation of membrane potential
negative regulation of synaptic transmission, glutamatergic
signal transduction
chemical synaptic transmission
transport
ion transport
synaptic transmission, glutamatergic
