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GSDMD Antibody (MA5-47002) in WB
Western blot analysis of GSDMD in untreated (–) and treated (+) THP-1 whole cell extracts (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with GSDMD Monoclonal antibody (Product # MA5-47002) using a dilution of 1:500 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
产品信息
MA5-47002
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1334
抗原
Recombinant protein encompassing a sequence within the center region of human Gasdermin D. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938074
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gasdermin domain containing 1; Gasdermin domain-containing protein 1; Gasdermin-D
基因别名: DF5L; DFNA5L; FKSG10; GSDMD; GSDMDC1
UniProt ID: (Human) P57764
Entrez Gene ID: (Human) 79792
