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GSK-3alpha Antibody (500-2914) in WB
Western Blot: The 3T3 cell lysate was resolved onto 10% SDS-PAGE, transferred onto NC membrane, and followed by an immunoblotting with Rabbit anti GSK-3 alpha (Cat#500-2914) antibody at 1:500 (lane 1). Lane 2 was pre-incubated with immunizing peptide. Observed a major immunoreactive band at molecular weight ~52 kDa.
产品信息
500-2914
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to N-terminus of human GSK3-alpha protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Positive control: 3T3 cell lysate
Cellular location: Cytoplasmic.
靶标信息
Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
基因别名: 2700086H06Rik; GSK3A
UniProt ID: (Human) P49840, (Rat) P18265, (Mouse) Q2NL51
Entrez Gene ID: (Human) 2931, (Rat) 50686, (Mouse) 606496
protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase A catalytic subunit binding
tau-protein kinase activity
protein kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of systemic arterial blood pressure
cardiac left ventricle morphogenesis
glycogen metabolic process
protein phosphorylation
dopamine receptor signaling pathway
nervous system development
insulin receptor signaling pathway
negative regulation of UDP-glucose catabolic process
Wnt signaling pathway
positive regulation of cAMP biosynthetic process
negative regulation of TOR signaling
cellular response to insulin stimulus
cellular response to interleukin-3
IRE1-mediated unfolded protein response
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of glycogen biosynthetic process
positive regulation of protein catabolic process
positive regulation of heart contraction
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
positive regulation of adrenergic receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
chemical synaptic transmission, postsynaptic
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
negative regulation of type B pancreatic cell development
negative regulation of glycogen (starch) synthase activity
positive regulation of glycogen (starch) synthase activity
regulation of gene expression by genetic imprinting
signal transduction
positive regulation of peptidyl-threonine phosphorylation
cell migration
positive regulation of peptidyl-serine phosphorylation
hypermethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transferase activity
cellular response to lithium ion
cellular response to organic cyclic compound
carbohydrate metabolic process
negative regulation of signal transduction
phosphorylation
