Proteintech

GSPT1 Polyclonal Antibody

GSPT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GSPT1 Antibody (10763-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 10763-1-AP (GSPT1 antibody) at dilution of 1:100 (under 10x lens).

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产品信息

10763-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

查看13篇已发表文章 13篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

查看4篇已发表文章 4篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GSPT1 Fusion Protein Ag1184 (265-633 aa encoded by BC009503)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: QEERDKGKT VEVGRAYFET EKKHFTILDA PGHKSFVPNM IGGASQADLA VLVISARKGE FETGFEKGGQ TREHAMLAKT AGVKHLIVLI NKMDDPTVNW SNERYEECKE KLVPFLKKVG FNPKKDIHFM PCSGLTGANL KEQSDFCPWY IGLPFIPYLD NLPNFNRSVD GPIRLPIVDK YKDMGTVVLG KLESGSICKG QQLVMMPNKH NVEVLGILSD DVETDTVAPG ENLKIRLKGI EEEEILPGFI LCDPNNLCHS GRTFDAQIVI IEHKSIICPG YNAVLHIHTC IEEVEITALI CLVDKKSGEK SKTRPRFVKQ DQVCIARLRT AGTICLETFK DFPQMGRFTL RDEGKTIAIG KVLKLVPEKD (265-633 aa encoded by BC009503)

靶标信息

eRF3a (eukaryotic peptide chain release factor subunit 3a), also known as GSPT1 (G1 to S phase transition 1), is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: eRF3a; Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; eukaryotic polypeptide chain release factor 3; G1 to phase transition 1; G1 to S phase transition protein 1; G1 to S phase transition protein 1 homolog; G1-to-S phase transition 1; G1-to-S transition GTP binding protein; guanine nucleotide regulatory protein

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基因别名: 551G9.2; AI314175; AI326449; AV307676; C79774; ERF3A; ETF3A; G1st; GSPT1; Gst-1; GST1

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UniProt ID: (Human) P15170, (Mouse) Q8R050

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Entrez Gene ID: (Human) 2935, (Rat) 24420, (Mouse) 14852

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功能

translation release factor activity GTPase activity protein binding GTP binding poly(A) RNA binding nucleotide binding translation factor RNA metabolism protein

参与通路

G1/S transition of mitotic cell cycle nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cytoplasmic translational termination protein methylation metabolic process translation translational termination