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Immunogen sequence: NVNDDNNNA GSGQQSVSVN NEHNVANVDN NNGWDSWNSI WDYGNGFAAT RLFQKKTCIV HKMNKEVMPS IQSLDALVKE KKLQGKGPGG PPPKGLMYSV NPNKVDDLSK FGKNIANMCR GIPTYMAEEM QEASLFFYSG TCYTTSVLWI VDISFCGDTV EN (35-196 aa encoded by BC059778)
Gastrokine 1, also known as GKN1 and CA11, is a 185 amino acid containing secreted protein belonging to the gastrokine family with a BRICHOS domain and an asn-rich region. GKN1 (also known as an antioncogene) is reported to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Differential display of normal and cancerous gastric tissue suggested that this protein is predominantly expressed in stomach and the expression is down-regulated to considerable frequency in cancer tissue or gastric cancer cell lines examined. This extra cellular protein is co-secreted with mucins and is a signaling growth factor with mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 18 kDa antrum mucosa protein; AMP-18; BRICHOS domain containing 1; foveolin; Gastrokine-1; Protein CA11; Protein CA11 homolog
基因别名: 2200002K21Rik; AMP-18; AMP18; BRICD1; CA11; FOV; foveolin; GKN1; UNQ489/PRO1005
UniProt ID: (Human) Q9NS71, (Mouse) Q9CR36
Entrez Gene ID: (Human) 56287, (Mouse) 66283