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Invitrogen
Gephyrin Recombinant Rabbit Monoclonal Antibody (ARC1109)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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Gephyrin Antibody (MA5-35565) in ICC/IF
Immunofluorescence analysis of Gephyrin was performed using 70% confluent log phase PC-3 and U-2 OS cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Gephyrin Recombinant Rabbit Monoclonal Antibody (ARC1109) (Product # MA5-35565) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody,... View More
产品信息
MA5-35565
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1109
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gephyrin (NP_001019389)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849465
产品详细信息
Immunogen sequence: MATEGMILTN HDHQIRVGVL TVSDSCFRNL AEDRSGINLK DLVQDPSLLG GTISAYKIVP DEIEEIKETL IDWCDEKELN LILTTGGTGF APRDVTPEAT
靶标信息
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Gephyrin; gephyrin isoform; Putative glycine receptor-tubulin linker protein
基因别名: 5730552E08Rik; AI662856; BC027112; C230040D23; GEPH; GPH; GPHN; GPHRYN; HKPX1; KIAA1385; MOCODC
UniProt ID: (Human) Q9NQX3, (Rat) Q03555, (Mouse) Q8BUV3
Entrez Gene ID: (Human) 10243, (Rat) 64845, (Mouse) 268566
protein binding
ATP binding
metal ion binding
molybdopterin adenylyltransferase activity
molybdopterin molybdotransferase activity
receptor binding
tubulin binding
protein binding, bridging
protein complex scaffold
protein homodimerization activity
nucleotide binding
catalytic activity
cytoskeletal protein binding
transferase activity
Mo-molybdopterin cofactor biosynthetic process
molybdenum incorporation into molybdenum-molybdopterin complex
molybdopterin cofactor biosynthetic process
glycine receptor clustering
gamma-aminobutyric acid receptor clustering
protein targeting
synapse assembly
establishment of synaptic specificity at neuromuscular junction
establishment of protein localization
protein homooligomerization
metabolic process
