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GluD1 Antibody (PA5-116486) in IHC (P)
Immunohistochemical analysis of GluD1 in a paraffin-embedded human breast carcinoma tissue using a GluD1 polyclonal antibody (Product #PA5-116486). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:20... View More
产品信息
PA5-116486
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human GLUD1 aa 115-164
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901117
产品详细信息
Positive controls: Hela cell lysate, HepG2 cell lysate, rat kidney tissue, human liver tissue, human liver carcinoma tissue, human colon carcinoma tissue, human breast carcinoma tissue, mouse liver tissue, SW620.
靶标信息
Glutamate dehydrogenase, GluD1, is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis tissue sperm binding protein Li 18mP; GDH 1; glutamate dehydrogenase (NAD(P)+); Glutamate dehydrogenase 1, mitochondrial; Memory-related gene 2 protein; MRG-2
基因别名: Ac2-281; AI118167; GDH; Gdh-X; GDH1; GLUD; GLUD1; Gludeha; Gludl; MRG-2
UniProt ID: (Human) P00367, (Mouse) P26443, (Rat) P10860
Entrez Gene ID: (Human) 2746, (Mouse) 14661, (Rat) 24399
glutamate biosynthetic process
glutamate catabolic process
glutamine metabolic process
cellular amino acid biosynthetic process
substantia nigra development
positive regulation of insulin secretion
oxidation-reduction process
tricarboxylic acid metabolic process
cellular amino acid metabolic process
response to aluminum ion
long-term memory
