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Glutamine Synthetase Antibody (PA5-86709) in WB
Western blot analysis of Glutamine Synthetase in Lane 1: MCF-7 cell lysate, Lane 2: mouse kidney tissue lysate, Lane 3: H9C2 cell lysate. Sample was incubated with Glutamine Synthetase polyclonal antibody (Product # PA5-86709) using a 1:500 dilution.
产品信息
PA5-86709
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 328-373 of Human GLUL.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803469
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell proliferation-inducing protein 59; GLNA; Glutamate ammonia ligase; glutamate decarboxylase; Glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; Glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; Proliferation inducing protein 43; proliferation-inducing protein 43
基因别名: GLNS; GLUL; GS; PIG43; PIG59
UniProt ID: (Human) P15104, (Mouse) P15105, (Rat) P09606
Entrez Gene ID: (Human) 2752, (Mouse) 14645, (Rat) 24957
neurotransmitter uptake
glutamate catabolic process
glutamine biosynthetic process
cell proliferation
cellular amino acid biosynthetic process
cellular response to starvation
response to glucose
ammonia assimilation cycle
positive regulation of insulin secretion
positive regulation of epithelial cell proliferation
protein homooligomerization
positive regulation of synaptic transmission, glutamatergic
glutamate metabolic process
nitrogen compound metabolic process
neurotransmitter metabolic process
