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Immunogen sequence: MAYPGYGGG FGNFSIQVPG MQMGQPVPET GPAILLDGYS GPAYSDTYSS AGDSVYTYFS AVAGQDGEVD AEELQRCLTQ SGINGTYSPF SLETCRIMIA MLDRDHTGKM GFNAFKELWA ALNAWKENFM TVDQDGSGTV EHHELRQAIG LMGYRLSPQT LTTIVKRYSK NGRIFFDDYV ACCVKLRALT DFFRKRDHLQ QGSANFIYDD FLQGTMAI (1-217 aa encoded by BC005214)
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Grancalcin; grancalcin, EF-hand calcium binding protein; grancalcin, EF-hand calcium-binding protein; grancalcin, penta-EF-hand protein; null
基因别名: 5133401E04Rik; AI573844; GCA; GCL
UniProt ID: (Human) P28676, (Mouse) Q8VC88
Entrez Gene ID: (Human) 25801, (Mouse) 227960, (Rat) 295647