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The protein encoded by this gene has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAD13; cadherin 13, H-cadherin (heart); Cadherin-13; CD39-like 3; CD39L3; ecto-apyrase 3; ecto-ATPase 3; ecto-ATPDase 3; H-cadherin; H-cadherin (heart); Heart cadherin; heart-cadherin; NTPDase-3; P105; T cad; T Cadherin; T-cad; T-cadherin; Truncated cadherin; truncated-cadherin
基因别名: 4932416G01Rik; CDH13; CDHH; Cdht; P105; T-cadherin; Tcad
UniProt ID: (Human) P55290, (Mouse) Q9WTR5
Entrez Gene ID: (Human) 1012, (Rat) 192248, (Mouse) 12554