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Immunogen sequence: MSGRSGKKK MSKLSRSARA GVIFPVGRLM RYLKKGTFKY RISVGAPVYM AAVIEYLAAE ILELAGNAAR DNKKARIAPR HILLAVANDE ELNQLLKGVT IASGGVLPRI HPELLAKKRG TKGKSETILS PPPEKRGRKA TSGKKGGKKS KAAKPRTSKK SKPKDSDKEG TSNSTSEDGP GDGFTILSSK SLVLGQKLSL TQSDISHIGS MRVEGIVHPT TAEIDLKEDI GKALEKAGGK EFLETVKELR KSQGPLEVAE AAVSQSSGLA AKFVIHCHIP QWGSDKCEEQ LEETIKNCLS AAEDKKLKSV AFPPFPSGRN CFPKQTAAQV TLKAISAHFD DSSASSLKNV YFLLFDSESI GIYVQEMAKL DAK (1-372 aa encoded by BC016172)
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; Histone macroH2A2; histone mH2A2; mH2A2
基因别名: H2AFY2; H2afy3; MACROH2A2; RGD1561371
UniProt ID: (Human) Q9P0M6, (Mouse) Q8CCK0
Entrez Gene ID: (Human) 55506, (Rat) 361844, (Mouse) 404634