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H3.3 G34W oncohistone mutant Antibody (703836) in ICC/IF
For immunofluorescence analysis, HEK-293 cells transfected with FLAG tagged H3.3 G34W construct were fixed and permeabilized with 0.5% Triton X-100 for detection of H3.3 G34W using Anti-H3.3 G34W Recombinant Rabbit Monoclonal Antibody (Product # 703836, 1:100 dilution) and labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790, 1:2000). Pan... View More
产品信息
703836
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4H32L4
抗原
Peptide corresponding to human H3.3G34W [aa30-aa39]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2895884
产品详细信息
This antibody is predicted to react with Mouse, Rat, Bovine.
靶标信息
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H3 histone, family 3B (H3.3B); H3.3; H3.3 G34W; H3B; H3FT; H3G34W; H3t; Histone 3.3; Histone cluster 3; Histone H3.3; Histone H3.3 G34W; Histone H3.3G34W
基因别名: H3-3A; H3-3B; H3.3A; H3.3B; H3F3; H3F3A; H3F3B; PP781
UniProt ID: (Human) P84243
Entrez Gene ID: (Human) 3020, (Human) 3021
chromatin silencing at rDNA
nucleosome assembly
DNA replication-independent nucleosome assembly
brain development
blood coagulation
response to hormone
positive regulation of cell growth
gene silencing by RNA
telomere organization
cellular protein metabolic process
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
