Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00009464-M03
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E3
抗原
HAND2 (NP_068808.1, 135 a.a. approximately 216 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: LSKIKTLRLA TSYIAYLMDL LAKDDQNGEA EAFKAEIKKT DVKEEKRKKE LNEILKSTVS SNDKKTKGRT GWPQHVWALE LK
靶标信息
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; Heart- and neural crest derivatives-expressed protein 2
基因别名: BHLHA26; DHAND; DHAND2; HAND2; Hed; Thing2
UniProt ID: (Human) P61296
Entrez Gene ID: (Human) 9464
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
AT DNA binding
transcription coactivator activity
protein binding
transcription factor binding
activating transcription factor binding
protein homodimerization activity
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
angiogenesis
in utero embryonic development
heart looping
suckling behavior
cardiac right ventricle formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
apoptotic process involved in heart morphogenesis
noradrenergic neuron differentiation
transcription from RNA polymerase II promoter
heart development
adult heart development
mesenchymal cell proliferation
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
regulation of tissue remodeling
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
tongue development
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
thymus development
peripheral nervous system neuron development
palate development
cartilage morphogenesis
coronary artery morphogenesis
visceral serous pericardium development
cardiac neural crest cell development involved in outflow tract morphogenesis
cell proliferation involved in outflow tract morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of p38MAPK cascade
positive regulation of transcription regulatory region DNA binding
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
