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Proteintech

HBB Polyclonal Antibody

10 篇参考文献

查看其他14个HBB抗体

货号 16216-1-AP

此产品在中国无法购买

150 µL

抗体检测数据 (5)

Application

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 5

HBB Antibody (16216-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver using 16216-1-AP (HBB antibody) at dilution of 1:100 (under 40x lens).

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HBB Antibody in Western Blot (WB)

HBB Antibody in Western Blot (WB)

HBB Antibody in Immunoprecipitation (IP)

Product Image Gallery

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver using 16216-1-AP (HBB antibody) at dilution of 1:100 (under 40x lens).

HBB Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver using 16216-1-AP (HBB antibody) at dilution of 1:100 (under 10x lens).

HBB Antibody in Western Blot (WB) — Human placenta tissue were subjected to SDS PAGE followed by western blot with 16216-1-AP (HBB antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

HBB Antibody in Western Blot (WB) — Human heart tissue were subjected to SDS PAGE followed by western blot with 16216-1-AP (HBB antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

HBB Antibody in Immunoprecipitation (IP) — IP result of anti-HBB (IP:16216-1-AP, 4ug; Detection:16216-1-AP 1:1000) with mouse heart tissue lysate 3200ug.

产品信息

16216-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

-

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

-

免疫沉淀 (IP)

0.5-4.0 µg

-

其他PubMed (Misc)

-

查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

-

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HBB Fusion Protein Ag9216 (1-147 aa encoded by BC007075)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody, raised against the full-length human HBB, recognizes the 13-16 kDa HBB in western blot analyses of human heart and placenta.

Immunogen sequence: MVHLTPEEK SAVTALWGKV NVDEVGGEAL GRLLVVYPWT QRFFESFGDL STPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFATL SELHCDKLHV DPENFRLLGN VLVCVLAHHF GKEFTPPVQA AYQKVVAGVA NALAHKYH (1-147 aa encoded by BC007075)

靶标信息

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon-gamma-G-gamma-A-delta-beta-3'.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model.

Nature communications

Hu M,Li T,Ma X,Liu S,Li C,Huang Z,Lin Y,Wu R,Wang S,Lu D,Lu T,Men X,Shen S,Huang H,Liu Y,Song K,Jian B,Jiang Y,Qiu W,Liu Q,Lu Z,Cai W

Tue Jul 04 00:00:00 UTC 2023

Identification of potential plasma markers for hepatitis B virus-related chronic hepatitis and liver fibrosis/cirrhosis.

Journal of medical virology

Zhao D,Yu S,Guo P,Zhang X,Tang Y,Dong C,Zhao S,Li L,Al-Dhamin Z,Ai R,Xue N,Dong S,Nan Y

Mon Aug 01 00:00:00 UTC 2022

Hemovasculogenic origin of blood vessels in the developing mouse brain.

The Journal of comparative neurology

Gama Sosa MA,De Gasperi R,Perez GM,Hof PR,Elder GA

Mon Feb 01 00:00:00 UTC 2021

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.

eLife

Riou R,Ladli M,Gerbal-Chaloin S,Bossard P,Gougelet A,Godard C,Loesch R,Lagoutte I,Lager F,Calderaro J,Dos Santos A,Wang Z,Verdier F,Colnot S

Wed Oct 21 00:00:00 UTC 2020

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription.

eLife

Riou R,Ladli M,Gerbal-Chaloin S,Bossard P,Gougelet A,Godard C,Loesch R,Lagoutte I,Lager F,Calderaro J,Dos Santos A,Wang Z,Verdier F,Colnot S

Wed Oct 21 00:00:00 UTC 2020

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Haematologica

Maio N,Kim KS,Holmes-Hampton G,Singh A,Rouault TA

Sun Sep 01 00:00:00 UTC 2019

Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)

Leung A,Zulick E,Skvir N,Vanuytsel K,Morrison TA,Naing ZH,Wang Z,Dai Y,Chui DHK,Steinberg MH,Sherr DH,Murphy GJ

Sun Jul 01 00:00:00 UTC 2018

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Blood cells, molecules & diseases

Morrison TA,Wilcox I,Luo HY,Farrell JJ,Kurita R,Nakamura Y,Murphy GJ,Cui S,Steinberg MH,Chui DHK

Thu Mar 01 00:00:00 UTC 2018

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Blood cells, molecules & diseases

Morrison TA,Wilcox I,Luo HY,Farrell JJ,Kurita R,Nakamura Y,Murphy GJ,Cui S,Steinberg MH,Chui DHK

Thu Mar 01 00:00:00 UTC 2018

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 UTC 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Thu Jun 02 00:00:00 UTC 2016

生物信息学

蛋白别名: beta globin chain; Beta-globin; hemoglobin beta; Hemoglobin beta chain; Hemoglobin subunit beta; hemoglobin, beta

基因别名: beta-globin; CD113t-C; HBB

UniProt ID: (Human) P68871

Entrez Gene ID: (Human) 3043

peroxidase activity oxygen transporter activity iron ion binding protein binding oxygen binding heme binding hemoglobin binding haptoglobin binding

参与通路

receptor-mediated endocytosis blood coagulation regulation of blood pressure positive regulation of cell death oxygen transport bicarbonate transport nitric oxide transport response to hydrogen peroxide hydrogen peroxide catabolic process positive regulation of nitric oxide biosynthetic process regulation of blood vessel size protein heterooligomerization renal absorption platelet aggregation cellular oxidant detoxification