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Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DNAX-activation protein 10; Hematopoietic cell signal transducer; kinase assoc pro of ~10kDa; kinase assoc protein; Membrane protein DAP10; phosphoinositide-3-kinase adaptor protein; Transmembrane adapter protein KAP10
基因别名: DAP10; HCST; KAP10; PIK3AP; UNQ587/PRO1157
UniProt ID: (Human) Q9UBK5, (Rat) Q6X9T8
Entrez Gene ID: (Human) 10870, (Rat) 474146