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HDAC1 Antibody (49-1025) in ChIP-seq
ChIP was performed on sheared chromatin from 4,000,000 HeLa cells using 2 µg of the anti-HDAC1 antibody (Product # 49-1025) as described above. The IP’d DNA was subsequently analysed on an Illumina HiSeq 2000. Library preparation, cluster generation and sequencing were performed according to the manufacturer’s instructions. The 50 bp tags were aligned to the human genome using the BWA algorithm. The figure shows the peak distribution along the complete sequence and a 1 Mb region of the X-chromosome (figure A and B) and in two regions surro... View More
产品信息
49-1025
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
raised in rabbits against the C-terminal region of human HDAC1, using a KLH-conjugated synthetic peptide.
偶联物
Unconjugated
形式
Liquid
浓度
1.73 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
RRID
AB_2533875
靶标信息
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
