Invitrogen

HDAC1 Monoclonal Antibody (E22)

查看其他38个HDAC1抗体

抗体检测数据 (3)

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HDAC1 Antibody (MA5-43779) in IHC (P)

Immunohistochemistry of HDAC1 in paraffin-embedded human small intestine tissue. Samples were incubated in monoclonal HDAC1 antibody (Product # MA5-43779) using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Western Blot (WB)

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HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of HDAC1 in paraffin-embedded human small intestine tissue. Samples were incubated in monoclonal HDAC1 antibody (Product # MA5-43779) using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of HDAC1 in paraffin-embedded human Colon tissue. Samples were incubated in monoclonal HDAC1 antibody (Product # MA5-43779) using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.

HDAC1 Antibody in Western Blot (WB) — Western blot analysis of HDAC1 in A549, Bovine testis Lung, HepG2, rat testis. Samples were incubated in monoclonal HDAC1 antibody (Product # MA5-43779).

产品信息

MA5-43779

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

-

免疫组化（石蜡） (IHC (P))

5-20 µg/mL

-

产品规格

种属反应

Bovine, Human, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

E22

抗原

Met1-Ala482 (Accession Q13547), with N-terminal His Tag

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2912711

靶标信息

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686H12203; HD1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2

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基因别名: GON-10; HD1; HDAC1; RPD3; RPD3L1

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UniProt ID: (Bovine) Q32PJ8, (Human) Q13547, (Rat) Q4QQW4

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Entrez Gene ID: (Bovine) 404126, (Human) 3065, (Rat) 297893

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histone deacetylase activity deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding core promoter binding RNA polymerase II transcription factor binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding enzyme binding nucleosomal DNA binding protein deacetylase activity activating transcription factor binding histone deacetylase binding transcription regulatory region DNA binding protein N-terminus binding NF-kappaB binding repressing transcription factor binding DNA binding chromatin binding transcription corepressor activity protein complex binding Krueppel-associated box domain binding

参与通路

circadian regulation of gene expression negative regulation of transcription, DNA-templated histone H4 deacetylation negative regulation of transcription from RNA polymerase II promoter chromatin remodeling methylation-dependent chromatin silencing transcription, DNA-templated protein deacetylation blood coagulation positive regulation of cell proliferation epidermal cell differentiation negative regulation of gene expression negative regulation of myotube differentiation positive regulation of receptor biosynthetic process viral process chromatin modification histone deacetylation odontogenesis of dentin-containing tooth embryonic digit morphogenesis ATP-dependent chromatin remodeling negative regulation of apoptotic process negative regulation by host of viral transcription positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of androgen receptor signaling pathway hair follicle placode formation eyelid development in camera-type eye fungiform papilla formation histone H3 deacetylation negative regulation of canonical Wnt signaling pathway regulation of signal transduction by p53 class mediator beta-catenin-TCF complex assembly response to amphetamine endoderm development circadian rhythm negative regulation of cell proliferation hippocampus development neuron differentiation response to caffeine response to lipopolysaccharide positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production cellular response to oxidative stress response to drug positive regulation of tyrosine phosphorylation of Stat3 protein negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process negative regulation of insulin secretion positive regulation of oligodendrocyte differentiation response to hyperoxia cellular response to tumor necrosis factor positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of type B pancreatic cell apoptotic process negative regulation of peptidyl-lysine acetylation negative regulation of intrinsic apoptotic signaling pathway