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产品信息
H00010013-M13
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A6
抗原
HDAC6 (AAH13737, 1 a.a. approximately 1063 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: METTQYMNEG ELRVLADTYD SVYLHPNSYS CACLASGSVL RLVDAVLGAE IRNGMAIIRP PGHHAQHSLM DGYCMFNHVA VAARYAQQKH RIRRVLIVDW DVHHGQGTQF TFDQDPSVLY FSIHRYEQGR FWPHLKASNW STTGFGQGQG YTINVPWNQV GMRDADYIAA FLHVLLPVAL EFQPQLVLVA AGFDALQGDP KGEMAATPAG FAQLTHLLMG LAGGKLILSL EGGYNLRALA EGVSASLHTL LGDPCPMLES PGAPCRSAQA SVSCALEALE PFWEVLVRST ETVERDNMEE DNVEESEEEG PWEPPVLPIL TWPVLQSRTG LVYDQNMMNH CNLWDSHHPE VPQRILRIMC RLEELGLAGR CLTLTPRPAT EAELLTCHSA EYVGHLRATE KMKTRELHRE SSNFDSIYIC PSTFACAQLA TGAACRLVEA VLSGEVLNGA AVVRPPGHHA EQDAACGFCF FNSVAVAARH AQTISGHALR ILIVDWDVHH GNGTQHMFED DPSVLYVSLH RYDHGTFFPM GDEGASSQIG RAAGTGFTVN VAWNGPRMGD ADYLAAWHRL VLPIAYEFNP ELVLVSAGFD AARGDPLGGC QVSPEGYAHL THLLMGLASG RIILILEGGY NLTSISESMA ACTRSLLGDP PPLLTLPRPP LSGALASITE TIQVHRRYWR SLRVMKVEDR EGPSSSKLVT KKAPQPAKPR LAERMTTREK KVLEAGMGKV TSASFGEEST PGQTNSETAV VALTQDQPSE AATGGATLAQ TISEAAIGGA MLGQTTSEEA VGGATPDQTT SEETVGGAIL DQTTSEDAVG GATLGQTTSE EAVGGATLAQ TTSEAAMEGA TLDQTTSEEA PGGTELIQTP LASSTDHQTP PTSPVQGTTP QISPSTLIGS LRTLELGSES QGASESQAPG EENLLGEAAG GQDMADSMLM QGSRGLTDQA IFYAVTPLPW CPHLVAVCPI PAAGLDVTQP CGDCGTIQEN WVCLSCYQVY CGRYINGHML QHHGNSGHPL VLSYIDLSAW CYYCQAYVHH QALLDVKNIA HQNKFGEDMP HPH
靶标信息
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ16239; HD6; HDA6; Histone deacetylase 6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6
基因别名: CPBHM; HD6; HDAC6; JM21; KIAA0901; PPP1R90
UniProt ID: (Human) Q9UBN7
Entrez Gene ID: (Human) 10013
core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
protein polyubiquitination
transcription, DNA-templated
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
organelle organization
negative regulation of microtubule depolymerization
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
positive regulation of receptor biosynthetic process
macroautophagy
histone deacetylation
regulation of protein stability
lysosome localization
peptidyl-lysine deacetylation
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of oxidoreductase activity
mitochondrion localization
response to misfolded protein
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
regulation of establishment of protein localization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
histone H3 deacetylation
cellular response to misfolded protein
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of mitophagy
