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产品信息
PA5-68563
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human HEY1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2689577
产品详细信息
This target displays homology in the following species: Cow: 79%; Dog: 79%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 100%
靶标信息
Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; MGC1274
基因别名: Herp2
Entrez Gene ID: (Rat) 155437
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
transcription factor activity, sequence-specific DNA binding
microsatellite binding
sequence-specific DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
blood vessel development
vasculogenesis
osteoblast development
outflow tract morphogenesis
atrioventricular valve morphogenesis
pulmonary valve morphogenesis
atrioventricular valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion to mesenchymal transition involved in heart valve formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
anterior/posterior axis specification
negative regulation of gene expression
mesenchymal cell development
dorsal aorta morphogenesis
umbilical cord morphogenesis
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cardiac epithelial to mesenchymal transition
cardiac septum morphogenesis
ventricular septum morphogenesis
labyrinthine layer blood vessel development
artery development
arterial endothelial cell differentiation
cellular response to glucocorticoid stimulus
negative regulation of transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
regulation of vasculogenesis
