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Proteintech

HEY2 Polyclonal Antibody

45 篇参考文献

查看其他10个HEY2抗体

说明书

实验方案

技术支持

货号 10597-1-AP

此产品在中国无法购买

150 µL

说明书

实验方案

技术支持

抗体检测数据 (9)

Application

HEY2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

HEY2 Antibody (10597-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using HEY2 antibody 10597-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

HEY2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HEY2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

10597-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看24篇已发表文章 24篇已发表文章

免疫组化 (IHC)

查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:50-1:500

查看7篇已发表文章 7篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看1篇已发表文章 1篇已发表文章

染色质免疫沉淀实验 (ChIP)

Assay-dependent

查看2篇已发表文章 2篇已发表文章

不适用 (N/A)

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HEY2 Fusion Protein Ag0913 (1-337 aa encoded by BC007707)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody is a rabbit polyclonal antibody raised against full length of human HEY2.

Immunogen sequence: MKRPCEETT SESDMDETID VGSENNYSGQ STSSVIRLNS PTTTSQIMAR KKRRGIIEKR RRDRINNSLS ELRRLVPTAF EKQGSAKLEK AEILQMTVDH LKMLQATGGK GYFDAHALAM DFMSIGFREC LTEVARYLSS VEGLDSSDPL RVRLVSHLST CATQREAAAM TSSMAHHHHP LHPHHWAAAF HHLPAALLQP NGLHASESTP CRLSTTSEVP PAHGSALLTA TFAHADSALR MPSTGSVAPC VPPLSTSLLS LSATVHAAAA AATAAAHSFP LSFAGAFPML PPNAAAAVAA ATAISPPLSV SATSSPQQTS SGTNNKPYRP WGTEVGAF (1-337 aa encoded by BC007707)

靶标信息

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

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MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice.

International journal of molecular medicine

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MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice.

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Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease.

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Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease.

American journal of physiology. Cell physiology

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Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease.

American journal of physiology. Cell physiology

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The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.

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Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.

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Wed Nov 21 00:00:00 UTC 2018

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.

Nature communications

Churko JM,Garg P,Treutlein B,Venkatasubramanian M,Wu H,Lee J,Wessells QN,Chen SY,Chen WY,Chetal K,Mantalas G,Neff N,Jabart E,Sharma A,Nolan GP,Salomonis N,Wu JC

Wed Nov 21 00:00:00 UTC 2018

MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3.

Cancer letters

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Wed Feb 01 00:00:00 UTC 2017

MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3.

Cancer letters

Jeong JY,Kang H,Kim TH,Kim G,Heo JH,Kwon AY,Kim S,Jung SG,An HJ

Wed Feb 01 00:00:00 UTC 2017

miR-150 enhances apoptotic and anti-tumor effects of paclitaxel in paclitaxel-resistant ovarian cancer cells by targeting Notch3.

Oncotarget

Kim TH,Jeong JY,Park JY,Kim SW,Heo JH,Kang H,Kim G,An HJ

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Cigarette smoke enhances initiation and progression of lung cancer by mutating Notch1/2 and dysregulating downstream signaling molecules.

Oncotarget

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Cigarette smoke enhances initiation and progression of lung cancer by mutating Notch1/2 and dysregulating downstream signaling molecules.

Oncotarget

Li W,Zhou J,Chen Y,Zhang G,Jiang P,Hong L,Shen Y,Wang X,Gong X

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Nature neuroscience

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Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.

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Wu LM,Wang J,Conidi A,Zhao C,Wang H,Ford Z,Zhang L,Zweier C,Ayee BG,Maurel P,Zwijsen A,Chan JR,Jankowski MP,Huylebroeck D,Lu QR

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Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells.

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Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells.

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Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor.

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Fujita M,Sakabe M,Ioka T,Watanabe Y,Kinugasa-Katayama Y,Tsuchihashi T,Utset MF,Yamagishi H,Nakagawa O

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DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms.

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EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway.

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EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway.

Oxidative medicine and cellular longevity

Xie H,Sun J,Chen Y,Zong M,Li S,Wang Y

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An important role of endothelial hairy-related transcription factors in mouse vascular development.

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Morioka T,Sakabe M,Ioka T,Iguchi T,Mizuta K,Hattammaru M,Sakai C,Itoh M,Sato GE,Hashimoto A,Fujita M,Okumura K,Araki M,Xin M,Pedersen RA,Utset MF,Kimura H,Nakagawa O

Sat Nov 01 00:00:00 UTC 2014

An important role of endothelial hairy-related transcription factors in mouse vascular development.

Genesis (New York, N.Y. : 2000)

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Sat Nov 01 00:00:00 UTC 2014

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.

Nature communications

Jiang H,Cheng XW,Shi GP,Hu L,Inoue A,Yamamura Y,Wu H,Takeshita K,Li X,Huang Z,Song H,Asai M,Hao CN,Unno K,Koike T,Oshida Y,Okumura K,Murohara T,Kuzuya M

Wed Jun 04 00:00:00 UTC 2014

Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.

Nature communications

Jiang H,Cheng XW,Shi GP,Hu L,Inoue A,Yamamura Y,Wu H,Takeshita K,Li X,Huang Z,Song H,Asai M,Hao CN,Unno K,Koike T,Oshida Y,Okumura K,Murohara T,Kuzuya M

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Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.

Blood

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Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.

Blood

Scheppke L,Murphy EA,Zarpellon A,Hofmann JJ,Merkulova A,Shields DJ,Weis SM,Byzova TV,Ruggeri ZM,Iruela-Arispe ML,Cheresh DA

Thu Mar 01 00:00:00 UTC 2012

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Somekawa S,Imagawa K,Hayashi H,Sakabe M,Ioka T,Sato GE,Inada K,Iwamoto T,Mori T,Uemura S,Nakagawa O,Saito Y

Tue Jul 24 00:00:00 UTC 2012

Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Somekawa S,Imagawa K,Hayashi H,Sakabe M,Ioka T,Sato GE,Inada K,Iwamoto T,Mori T,Uemura S,Nakagawa O,Saito Y

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Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population.

Circulation. Cardiovascular genetics

Li H,Cherry S,Klinedinst D,DeLeon V,Redig J,Reshey B,Chin MT,Sherman SL,Maslen CL,Reeves RH

Fri Jun 01 00:00:00 UTC 2012

Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population.

Circulation. Cardiovascular genetics

Li H,Cherry S,Klinedinst D,DeLeon V,Redig J,Reshey B,Chin MT,Sherman SL,Maslen CL,Reeves RH

Fri Jun 01 00:00:00 UTC 2012

Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population.

Circulation. Cardiovascular genetics

Li H,Cherry S,Klinedinst D,DeLeon V,Redig J,Reshey B,Chin MT,Sherman SL,Maslen CL,Reeves RH

Fri Jun 01 00:00:00 UTC 2012

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.

Current biology : CB

Fujitani M,Cancino GI,Dugani CB,Weaver IC,Gauthier-Fisher A,Paquin A,Mak TW,Wojtowicz MJ,Miller FD,Kaplan DR

Tue Nov 23 00:00:00 UTC 2010

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.

Current biology : CB

Fujitani M,Cancino GI,Dugani CB,Weaver IC,Gauthier-Fisher A,Paquin A,Mak TW,Wojtowicz MJ,Miller FD,Kaplan DR

Tue Nov 23 00:00:00 UTC 2010

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.

PLoS genetics

Tokuzawa Y,Yagi K,Yamashita Y,Nakachi Y,Nikaido I,Bono H,Ninomiya Y,Kanesaki-Yatsuka Y,Akita M,Motegi H,Wakana S,Noda T,Sablitzky F,Arai S,Kurokawa R,Fukuda T,Katagiri T,Schönbach C,Suda T,Mizuno Y,Okazaki Y

Thu Jul 08 00:00:00 UTC 2010

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.

PLoS genetics

Thu Jul 08 00:00:00 UTC 2010

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.

Oncogene

Raafat A,Lawson S,Bargo S,Klauzinska M,Strizzi L,Goldhar AS,Buono K,Salomon D,Vonderhaar BK,Callahan R

Thu Jan 15 00:00:00 UTC 2009

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.

Oncogene

Raafat A,Lawson S,Bargo S,Klauzinska M,Strizzi L,Goldhar AS,Buono K,Salomon D,Vonderhaar BK,Callahan R

Thu Jan 15 00:00:00 UTC 2009

生物信息学

蛋白别名: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; h hHRT2; hairy and enhancer of split related 2; Hairy and enhancer of split-related protein 2; Hairy-E(spl)-related with YRPW motif 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hHRT2; HRT-2; mHRT2; Protein gridlock homolog

基因别名: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2

UniProt ID: (Human) Q9UBP5, (Mouse) Q8CD44

Entrez Gene ID: (Human) 23493, (Mouse) 15214

功能

transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding RNA polymerase II activating transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding microsatellite binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding protein heterodimerization activity DNA binding protein dimerization activity basic helix-loop-helix transcription factor

参与通路

HEY2 Polyclonal Antibody

HEY2 Antibody (10597-1-AP) in ICC/IF

产品信息

10597-1-AP

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

染色质免疫沉淀实验 (ChIP)

不适用 (N/A)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

HEY2 Polyclonal Antibody

HEY2 Antibody (10597-1-AP) in ICC/IF

产品信息

10597-1-AP

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

染色质免疫沉淀 实验 (ChIP)

不适用 (N/A)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

染色质免疫沉淀实验 (ChIP)