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HEY2 Monoclonal Antibody (2B10)

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HEY2 Antibody in Western Blot (WB)

HEY2 Antibody in Western Blot (WB)

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HEY2 Antibody (H00023493-M02) in WB

HEY2 monoclonal antibody (M02), clone 2B10. Western Blot analysis of HEY2 expression in human pancreas.

HEY2 Antibody in Western Blot (WB)

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HEY2 Antibody in Western Blot (WB) — HEY2 monoclonal antibody (M02), clone 2B10. Western Blot analysis of HEY2 expression in human pancreas.

产品信息

H00023493-M02

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2B10

抗原

HEY2 (NP_036391.1, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.47 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Tissue lysate).

Immunogen sequence: MKRPCEETTS ESDMDETIDV GSENNYSGQS TSSVIRLNSP TTTSQIMARK KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG

靶标信息

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; h hHRT2; Hairy and enhancer of split-related protein 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hHRT2; HRT-2; Protein gridlock homolog

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基因别名: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2

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UniProt ID: (Human) Q9UBP5

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Entrez Gene ID: (Human) 23493

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transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding RNA polymerase II activating transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding microsatellite binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding protein heterodimerization activity basic helix-loop-helix transcription factor

参与通路

negative regulation of transcription from RNA polymerase II promoter vasculogenesis muscular septum morphogenesis outflow tract morphogenesis pulmonary valve morphogenesis tricuspid valve morphogenesis tricuspid valve formation endocardial cushion to mesenchymal transition involved in heart valve formation cardiac ventricle morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis transcription, DNA-templated Notch signaling pathway anterior/posterior axis specification positive regulation of heart rate negative regulation of transcription by transcription factor localization negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development cardiac muscle hypertrophy in response to stress ascending aorta morphogenesis dorsal aorta morphogenesis umbilical cord morphogenesis cell fate commitment regulation of auditory receptor cell differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition heart trabecula formation cardiac septum morphogenesis ventricular septum morphogenesis atrial septum morphogenesis negative regulation of transcription initiation from RNA polymerase II promoter labyrinthine layer blood vessel development arterial endothelial cell differentiation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis pulmonary artery morphogenesis Notch signaling involved in heart development protein-DNA complex assembly cochlea development vascular smooth muscle cell development negative regulation of transcription regulatory region DNA binding negative regulation of cardiac vascular smooth muscle cell differentiation negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation regulation of vasculogenesis