Abnova

HIP1 Monoclonal Antibody (1F12)

HIP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HIP1 Antibody (H00003092-M01) in IHC (P)

Immunoperoxidase of monoclonal antibody to HIP1 on formalin-fixed paraffin-embedded human colon. Antibody concentration is 3 µg/mL.

HIP1 Antibody in Immunoprecipitation (IP)

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产品信息

H00003092-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

免疫组化（石蜡） (IHC (P))

3 µg/mL

酶联免疫吸附实验 (ELISA)

0.3 ng/mL

免疫沉淀 (IP)

1-5 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

1F12

抗原

HIP1 (NP_005329, 928 a.a. approximately 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: DSPNLAQLQQ ASRGVNQATA GVVASTISGK SQIEETDNMD FSSMTLTQIK RQEMDSQVRV LELENELQKE RQKLGELRKK HYELAGVAEG WEEGTEASPP TLQEVVTEKE

靶标信息

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。