Bioss

HIP55 Polyclonal Antibody

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HIP55 Antibody (BS-20165R) in WB

Lane 1: mouse lymph lysates; Lane 2: mouse spleen lysates probed with HIP55 Polyclonal Antibody, Unconjugated (bs-20165R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.

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产品信息

BS-20165R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300

免疫组化（石蜡） (IHC (P))

1:200-1:400

免疫组化（冰冻） (IHC (F))

1:100-1:500

免疫细胞化学 (ICC/IF)

1:100-1:500

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human HIP55, amino acids 201-300.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Actin-binding protein 1; Cervical mucin-associated protein; Cervical SH3P7; dbnl; drebrin F; Drebrin-F; drebrin-like; Drebrin-like protein; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; src homology 3 domain-containing protein HIP-55

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基因别名: ABP1; CMAP; DBNL; HIP-55; HIP55; mAbp1; PP5423; SH3P7

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UniProt ID: (Human) Q9UJU6, (Mouse) Q62418

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Entrez Gene ID: (Human) 28988, (Mouse) 13169

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功能

actin binding protein binding protein C-terminus binding enzyme activator activity protein domain specific binding actin filament binding cadherin binding involved in cell-cell adhesion actin or actin-binding cytoskeletal protein cytoskeletal protein non-motor actin binding protein

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