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Invitrogen
HMGA2 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 13
HMGA2 Antibody (PA5-21320) in ICC/IF
HMGA2 antibody detects HMGA2 protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: HMGA2 protein stained by HMGA2 antibody (Product # PA5-21320) diluted at 1:500. Red: Phalloidin, a cytoskeleton marker, diluted at 1:200. Scale bar = 10 μm.
产品信息
PA5-21320
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 109 of HMGA2 (Uniprot ID#P52926)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11155799
产品详细信息
Recommended positive controls: A431, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (95%), Rat (92%), Zebrafish (85%), Xenopus laevis (80%), Chicken (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high mobility group protein I, isoform C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; non-histone chromosomal architectural protein HMGI-C
基因别名: 9430083A20Rik; BABL; HMGA2; HMGI-C; HMGIC; LIPO; pg; pygmy; STQTL9
UniProt ID: (Human) P52926, (Mouse) P52927
Entrez Gene ID: (Human) 8091, (Mouse) 15364, (Rat) 84017
regulatory region DNA binding
transcription factor activity, transcription factor binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
AT DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
DNA-dependent protein kinase activity
protein binding
transcription factor binding
DNA binding, bending
nucleosomal DNA binding
cAMP response element binding
MH2 domain binding
MH1 domain binding
SMAD binding
5'-deoxyribose-5-phosphate lyase activity
C2H2 zinc finger domain binding
enzyme binding
transcription factor activity, sequence-specific DNA binding
endodeoxyribonuclease
negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
chondrocyte differentiation
mesodermal-endodermal cell signaling
base-excision repair
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
mitotic G2 DNA damage checkpoint
multicellular organism development
response to virus
regulation of cell cycle process
positive regulation of gene expression
chromosome condensation
chromosome breakage
heterochromatin assembly
histone H2A-S139 phosphorylation
senescence-associated heterochromatin focus assembly
endodermal cell differentiation
chondrocyte proliferation
regulation of growth
DNA damage response, detection of DNA damage
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
fat cell differentiation
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
mesenchymal cell differentiation
stem cell differentiation
cell division
positive regulation of cell cycle arrest
oncogene-induced cell senescence
regulation of stem cell population maintenance
positive regulation of stem cell proliferation
positive regulation of transcription regulatory region DNA binding
positive regulation of cellular response to X-ray
positive regulation of cellular senescence
positive regulation of response to DNA damage stimulus
negative regulation of double-strand break repair via nonhomologous end joining
regulation of cellular response to drug
transcription, DNA-templated
cell cycle
signal transduction
spermatogenesis
cell proliferation
positive regulation of cell proliferation
male gonad development
cell proliferation in forebrain
pituitary gland development
adrenal gland development
negative regulation of intracellular steroid hormone receptor signaling pathway
somatic stem cell population maintenance
positive regulation of multicellular organism growth
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
meiotic cell cycle
regulation of growth hormone secretion
adipose tissue development
fat pad development
regulation of peptide hormone secretion
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
