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产品信息
PA5-51183
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length fusion protein of human HMGN3
偶联物
Unconjugated
形式
Liquid
浓度
1.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636631
产品详细信息
The antibody detects endogenous levels of total HMGN3 protein.
靶标信息
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: High mobility group nucleosome-binding domain-containing protein 3; thyroid hormone receptor interacting protein 7; Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7
基因别名: 1110002A15Rik; 6330514M13Rik; BB071015; HMGN3; PNAS-24; PNAS-25; TRIP7
UniProt ID: (Human) Q15651, (Mouse) Q9DCB1
Entrez Gene ID: (Human) 9324, (Mouse) 94353
biological_process
covalent chromatin modification
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of transcription from RNA polymerase II promoter
chromatin modification
positive regulation of sequence-specific DNA binding transcription factor activity
