Invitrogen

HNF6 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他7个HNF6抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (6)
高级验证 (1)

HNF6 Antibody in Immunocytochemistry (ICC/IF)

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HNF6 Antibody (PA5-79770) in ICC/IF

Immunocytochemistry analysis of HNF6 in HCT116 cells. Sample was incubated with HNF6 polyclonal antibody (Product # PA5-79770).

HNF6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HNF6 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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HNF6 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines owing to their inherent genetic constitution. Relative expression of HNF6 was observed in Hep G2 (High expressing) and HeLa (Medium expressing) and not in SK-O-V3 and NIH: OVCAR-3, using Anti-HNF6 Polyclonal Antibody (Product # PA5-79770) in Western Blot. {RE}

产品信息

PA5-79770

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

免疫组化（冰冻） (IHC (F))

0.5-1 µg/mL

免疫细胞化学 (ICC/IF)

0.5-1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the N-terminus of human HNF6 (187-203aa LGSIHNSQQGLPHYAHP).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide, 0.05mg thimerosal

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2746885

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: hepatic nuclear factor 6; Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-3/forkhead homolog 12; HNF-6; One cut domain family member 1; one cut domain, family member 1; One cut homeobox 1

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基因别名: D9Ertd423e; Hfh12; HNF-6; HNF6; HNF6A; Hnf6b; OC-1; Oc1; ONECUT1

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UniProt ID: (Human) Q9UBC0, (Mouse) O08755, (Rat) P70512

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Entrez Gene ID: (Human) 3175, (Mouse) 15379, (Rat) 25231

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功能

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding homeodomain transcription factor

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