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Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-6; One cut domain family member 1; One cut homeobox 1
基因别名: HNF-6; HNF6; HNF6A; ONECUT1
UniProt ID: (Human) Q9UBC0
Entrez Gene ID: (Human) 3175